Dr. Rodwick, HIV AIDS, transgender, hepatitis C, Clearwater, FL, AAHIVM, WPATH, testosterone, Sculptra

Forms of Testosterone Supplements

Testosterone replacement therapy is available in several forms. All can improve testosterone levels:

  • Skin patch (transdermal): Androderm and Testoderm are avai;able as a skin patch that is worn on the arm or upper body. It's applied once a day. It is possible to have skin irritation (may be mild, may be severe) at the site that the patch is applied.
  • Gels: AndroGel and Testim come in packets or tubes of clear testosterone gel. Testosterone is absorbed directly through the skin when you apply the gel once a day. AndroGel, Axiron (actually a solution, not a gel), and Fortesta also come in a pump that delivers the amount of testosterone prescribed by your doctor.
  • Mouth patch: Striant is a tablet that sticks to the upper gums above the incisor, the tooth just to the right or left of the two front teeth. Applied twice a day, it continuously releases testosterone into the blood through the oral tissues.
  • Injections and implants: Testosterone can also be injected directly into the muscles, or implanted as pellets in the soft tissues. Your body slowly absorbs the testosterone into the bloodstream. The injeections are most often administered every 2 weeks and can usually be done at home. The Testopel pellets are implanted by a physician in the office during a procedure that takes about 10 minutes, however the effects can last for 4-5 months and eliminate the need for daily applications of gel or biweekly injections.

Why not a simple testosterone pill? Oral testosterone is available. However, some experts believe oral testosterone can have negative effects on the liver. Using other methods, such as skin patches, gels, orally disintegrating tablets, or injections, bypasses the liver and gets testosterone into the blood directly.

Potential non-approved uses:

Anemia, anxiety, breast cancer (women), severe burns, prostate cancer, cluster headache, cognitive function finding, penis enlargement, male contraception, coronary arteriosclerosis, testosterone deficiency (women), delayed puberty (male), depression, female-to-male transsexual (gender identity disorder), postmenopausal hormone replacement therapy, male infertility, osteoporosis (male), portal cirrhosis, postmenopausal osteoporosis prophylaxis, sexual disorders, weight gain

Testosterone Products:

Usual Dose:

Estimated Cost for 30-day supply:

testosterone topical gel 1% (AndroGel® 2.5 and 5 gm packet, AndroGel Pump® 1.25 gm/actuation) 5 gm gel (4 actuations) delivers 50 mg of testosterone

1 packet or 4 pumps (50 mg) once daily to shoulders, upper arms, or abdomen $325.00

testosterone topical gel 2% (Fortesta®) 4 actuations (2 gm gel) delivers 40 mg of testosterone

4 pumps (40 mg) once daily to thighs $263.00-458.00

testosterone topical gel 1% (Testim Gel® 5 gm packet) 5 gm gel delivers 50 mg of testosterone

1 tube (50 mg) once daily to shoulders and upper arms $310.00

testosterone topical solution (Axiron®) 2 actuations (3 mL) delivers 60 mg of testosterone

2 pumps (60 mg) once daily (1 pump to each armpit) $242.00-483.00
testosterone transdermal patch 2-4 mg/24 hours (Androderm®) 1 patch (4 mg) once nightly to back, thighs, abdomen, or upper arms $289.00
testosterone enanthate injection in oil 200 mg/mL (generic Delatestryl®)
200 mg intramuscular injection every 2 weeks (or 100 mg once weekly) $82.00
testosterone cypionate in oil injection 100-200 mg/mL (generic Depo-Testosterone®)
200 mg intramuscular injection every 2 weeks (or 100 mg once weekly) $66.00
testosterone pellet implant 75 mg (Testopel®) 10-12 pellets (750-900 mg) implanted in physician's office every 4-5 months $650.00 for 3-5 month course
testosterone 30 mg extended-release buccal tablets (Striant®) 1 tablet (30 mg) buccally twice daily $226.00
methyltestosterone 10 and 25 mg oral capsule (generic, Testred, Methitest)
10-50 mg orally daily $166.00
testosterone 2% cream (First-Testosterone MC®)
testosterone 2% ointment (First-Testosterone®)
Not FDA-approved  

Some things to consider:

+ Hypogonadism (testosterone deficiency) is a very common disease.
+ There is no evidence comparing any branded Testosterone Replacement Therapy (TRT) formulations.
+ There is no conclusive evidence of long-term health benefits (decreased fracture rate, cardiovascular risk or improved quality of life) of TRT
+ TRT is available as intramuscular (IM), implant, oral and topical (gel, solution, patch) formulations.
+ One method of administration is no more effective than another.
+ There are no proven efficacy differences between formulations.
+ Intramuscular formulations may be self- or office- administered, and can be associated with pain.
+ Erythrocytosis (elevated red blood cell count), acne and prostatic enlargement are known effects of TRT.
+ Testosterone gels or solutions have the potential for skin transfer to another person, with possible physical effects, though reported rarely.
+ Testosterone patch (Androderm) is associated with skin reactions more commonly than other topical testosterone gels or solutions.
+ Oral methyltestosterone is associated with liver toxicity.
+ The effectiveness of TRT is monitored by assessing serum testosterone level, as well as improvement in sexual function, mood, fatigue, bone mineral density (BMD), and well-being.
+Practice Guidelines consider TRT to be the standard of care for treatment of men with hypogonadism. All products are considered effective; Choice is based on patient preference, treatment burden, pharmacokinetics, and cost. Guidelines recommend against use of TRT for women.

The fine print: The content of this website is provided for general informational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice. Do not use the information on this website for diagnosing or treating any medical or health condition. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.